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Reserve concomitant prescribing of such medications in clients for whom other procedure solutions are inadequate. Restrict dosages and durations on the bare minimum demanded. Check closely for indications of respiratory depression and sedation.
La codeina è un analgesico dotato anche di effetto antitussigeno. Agisce modificando il modo in cui il cervello e il sistema nervoso rispondono al dolore e riducendo l'attività delle aree cerebrali che controllano la tosse.
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Keep an eye on Carefully (one)desvenlafaxine will raise the degree or impact of codeine by impacting hepatic enzyme CYP2D6 metabolism.
Codeine is contraindicated in people who are recognized to get ultrafast CYP2D6 metabolisers: Codeine is transformed in its Energetic metabolite morphine through the hepatic isoenzymes CYP2D6, a number of which exist with genetic polymorphisms.
Gli oppioidi agiscono legandosi agli specifici recettori (recettori degli oppioidi), che si trovano principalmente nel sistema nervoso centrale e periferico e nel tratto gastrointestinale.